文章基本信息

标题：Small Bowel Tissue Concentration of Rebamipide: Study of Two Dosages in Healthy Subjects
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作者：Taiji Akamatsu ; Tadanobu Nagaya ; Shinya Ichikawa 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2010
卷号：47
期号：3
页码：256-260
DOI：10.3164/jcbn.10-86
出版社：The Society for Free Radical Research Japan
摘要：Non-steroidal anti-inflammatory drug (NSAID)-related small intestinal complications exist, since developed new diagnostic modalities, such as balloon and capsule endoscopies. Some experiments have shown rebamipide to protect from NSAID-induced small intestinal complications. The purpose of this study is to investigate whether the effective concentrations of rebamipide (COR) are present in the small intestine after taking an ordinary clinical dose and double dose of this drug. Twelve healthy male subjects were enrolled. After taking 100 or 200 mg of rebamipide, balloon enteroscopy was performed at 1 and 3 h, and biopsy samples were obtained from the jejunum and the stomach. Venous blood samples were taken simultaneously. Samples were analyzed by high-performance liquid chromatography. The mean COR in the jejunum was higher than 100 μM at 1 h and higher than 10 μM at 3 h in both the 100 and 200 mg groups. Mean COR in the stomach was less than 100 μM at 1 h in the 100 mg group; however it was higher than 100 μM in the 200 mg group. In conclusion, the COR level in the jejunum was sufficient to protect for NSAID-induced gastrointestinal complications.
关键词：rebamipide;local concentration;small intestine;balloon enteroscopy