文章基本信息

标题：Relationship between Pentosidine and Pyridinoline Levels in Human Diabetic Cataract Lenses
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作者：Hirotaka Hashimoto ; Kiyomi Arai ; Makoto Chikuda 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2010
卷号：47
期号：3
页码：233-237
DOI：10.3164/jcbn.10-50
出版社：The Society for Free Radical Research Japan
摘要：The relationship between the levels of two different crosslink compounds, pentosidine and pyridinoline, in human diabetic cataract lenses was investigated to elucidate the pathogenic mechanism of diabetic cataract. Subjects were classified into diabetes mellitus (DM) group and non-DM group according to the presence or absence of DM. The levels of the crosslink compounds were determined using high-performance liquid chromatography and spectrofluorometry after acid hydrolysis. In the non-DM group the pentosidine level was significantly and positively correlated with the pyridinoline level and age. In the DM group the pentosidine level was not significantly correlated with either pyridinoline level or age. Pyridinoline levels and age were not significantly correlated in either group. The increase in crosslink compounds due to glycation and the relationship between the compounds are changed in DM lenses.
关键词：pentosidine;pyridinoline;crosslink;glycation;lens