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标题：Protective Effects of Vitamin E Analogs against Carbon Tetrachloride-Induced Fatty Liver in Rats
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作者：Rieko Yachi ; Osamu Igarashi ; Chikako Kiyose 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2010
卷号：47
期号：2
页码：148-154
DOI：10.3164/jcbn.10-35
出版社：The Society for Free Radical Research Japan
摘要：Recently, it has been reported that α-tocopherol (α-Toc) is effective for amelioration of liver damage. However, it is unknown whether other vitamin E analogs are effective. In this study, we investigated the effects of γ-tocopherol (γ-Toc) and tocotrienols (T3) in rats with fatty liver. Rats fed a vitamin E-deficient diet for four weeks were divided into eight groups: Control, carbon tetrachloride (CCl₄), α-Toc, α-Toc + CCl₄, γ-Toc, γ-Toc + CCl₄, T3 mix, T3 mix + CCl₄. After a 24 h fast, the rats were administered 20 mg of each of the vitamin E analogs, respectively. Moreover, the CCl₄ group were given 0.5 ml/kg body weight corn oil preparation containing CCl₄ 6 h after vitamin E administration. We measured the activities of aspartate aminotransferase and alanine aminotransferase (ALT) in plasma, and the contents of triglyceride (TG), total cholesterol (T-Chol) and vitamin E analogs in the liver. Also, we determined the hepatic expression of mRNA for inflammatory cytokines. The liver TG content in the γ-Toc + CCl₄ and T3 mix + CCl₄ groups was decreased in comparison with the CCl₄ group. Moreover, ALT activity in the T3 mix + CCl₄ group was significantly lower than CCl₄ group. These findings suggest that γ-Toc and T3 are effective for amelioration of fatty liver.
关键词：γ-tocopherol;tocotrienol;fatty liver;carbon tetrachloride