文章基本信息

标题：F2-Isoprostanes as Novel Biomarkers for Type 2 Diabetes: a Review
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作者：Subramanian Kaviarasan ; Sekaran Muniandy ; Rajes Qvist 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2009
卷号：45
期号：1
页码：1-8
DOI：10.3164/jcbn.08-266
出版社：The Society for Free Radical Research Japan
摘要：Oxidative stress (OS) has been implicated as one of the major underlying mechanisms behind many acute and chronic diseases. However, the measurement of free radicals or their end products is complicated. Isoprostanes, derived from the non-enzymatic peroxidation of arachidonic acid are now considered to be reliable biomarkers of oxidant stress in the human body. Isoprostanes are involved in many of the human diseases such as type 2 diabetes. In type 2 diabetes elevated levels of F₂-Isoprostanes (F₂-IsoPs) have been observed. The measurement of bioactive F₂-IsoPs levels offers a unique noninvasive analytical tool to study the role of free radicals in physiology, oxidative stress-related diseases, and acute or chronic inflammatory conditions. Measurement of oxidative stress by various other methods lacks specificity and sensitivity. This review aims to shed light on the implemention of F₂-IsoPs measurement as a gold-standard biomarker of oxidative stress in type 2 diabetics.
关键词：oxidative stress;lipid peroxidation;isoprostanes;type 2 diabetes