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标题：Role of Vitamins C and E in Regulating Antioxidant and Pro-Oxidant Markers in Preeclampsia
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作者：Mohd Suhail ; Mohd Faizul Suhail ; Hina Khan 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2008
卷号：43
期号：3
页码：210-220
DOI：10.3164/jcbn.2008067
出版社：The Society for Free Radical Research Japan
摘要：We compared three groups of pregnant women: placebo with normotensive women, group A which included preeclamptics, and group B which comprised preeclamptics who were supplemented their diets with vitamins C and E. MDA increased from 6.22 ± 2.8 (placebo) to 8.48 ± 1.2 (A) and 8.02 ± 1.8 nmol/gHb (B). NO concentrations were enhanced from 19.3 ± 4.2 (P) to 23.8 ± 6.4 (A) and 24.1 ± 5.4 μmol/L (B). GSH contents were decreased from 10.42 ± 2.81 (P) to 8.02 ± 2.92 (A) and 9.39 ± 1.02 μmol/g Hb (B), whereas GSSG concentrations increased from 0.98 ± 0.28 (P) to 1.24 ± 0.29 (A) and 1.08 ± 0.12 μmol/g Hb (B). SOD activity decreased 23% in A and 14% in B; GRx decreased 27% in A and 5.5% in B; GPx decreased 12% in A and 9.6% in B. Catalase activity, however, increased 27% in A and 29% in B as compared to control. Thus, we conclude that the use of vitamins C and E should be considered for the control of certain important biochemical indices during the development of preeclampsia; however, further studies are needed to develop methods for the prevention of preeclampsia in women at high risk.
关键词：vitamin C & E;antioxidants & pro-oxidants;enzymatic & non-enzymatic;preeclampsia