文章基本信息

标题：Protective Effects of Coenzyme Q10 on Decreased Oxidative Stress Resistance Induced by Simvastatin
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作者：Aikkarach Kettawan ; Takayuki Takahashi ; Ratchanee Kongkachuichai 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2007
卷号：40
期号：3
页码：194-202
DOI：10.3164/jcbn.40.194
出版社：The Society for Free Radical Research Japan
摘要：The effects of simvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl CoA reductase (HMG-CoA reductase), on oxidative stress resistance and the protective effects of coenzyme Q (CoQ) were investigated. When simvastatin was administered orally to mice, the levels of oxidized and reduced CoQ₉ and CoQ₁₀ in serum, liver, and heart, decreased significantly when compared to those of control. The levels of thiobarbituric acid reactive substances induced by Fe²⁺-ascorbate in liver and heart mitochondria also increased significantly with simvastatin. Furthermore, cultured cardiac myocytes treated with simvastatin exhibited less resistance to oxidative stress, decreased time to the cessation of spontaneous beating in response to H₂O₂ addition, and decreased responsiveness to electrical field stimulation. These results suggested that oral administration of simvastatin suppresses the biosynthesis of CoQ, which shares the same biosynthesis pathway as cholesterol up to farnesyl pyrophosphate, thus compromising the physiological function of reduced CoQ, which possesses antioxidant activity. However, these undesirable effects induced by simvastatin were alleviated by coadministering CoQ₁₀ with simvastatin to mice. Simvastatin also reduced the activity of NADPH-CoQ reductase, a biological enzyme that converts oxidized CoQ to the corresponding reduced CoQ, while CoQ₁₀ administration improved it. These findings may also support the efficacy of coadministering CoQ₁₀ with statins.
关键词：coenzyme Q10;ubiquinol-10;HMG-CoA reductase inhibitor;statin;oxidative stress