文章基本信息

标题：Inhibitory Effect of Long Term 1α-Hydroxyvitamin D3 Administration on Helicobacter pylori Infection
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作者：Akihiko Kawaura ; Eiji Takeda ; Noritoshi Tanida 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2006
卷号：38
期号：2
页码：103-106
DOI：10.3164/jcbn.38.103
出版社：The Society for Free Radical Research Japan
摘要：The effects of long-term supplementation with 1α-hydroxyvitamin D₃ (1α (OH) D₃) on serum pepsinogen (PG) I levels, and Helicobacter pylori ( H. pylori ) infection rate, were investigated in healthy elderly women, aged 70 to 99 years, in a nursing home. Of these 34 subjects, 15 have been administered one microgram of 1α (OH) D₃ daily for twenty years, because of osteoporosis treatment, and 19 were free from the drug. Serum PG-I levels and H. pylori infection rate in subjects with 1α (OH) D₃ were significantly lower than those without treatment (p<0.05). These results suggested the inhibitory effect of long-term administration of 1α (OH) D₃ on H. pylori infection.
关键词：1α-hydroxyvitamin D3;Helicobacter pylori;pepsinogen I;elderly women;nursing home