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标题：Diallyl Disulfide-Induced Modulation of a Few Phase I and II Drug Metabolizing Enzymes on Aroclor 1254 Toxicity in Rattus norvegicus Liver and Ventral Prostate
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作者：Sivanantham Banudevi ; Arumugam Arunkumar ; Mohandhas Sharmila 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2005
卷号：36
期号：3
页码：59-65
DOI：10.3164/jcbn.36.59
出版社：The Society for Free Radical Research Japan
摘要：Polychlorinated biphenyls (PCBs) are persistent bioaccumulative toxicants. These synthetic organochlorinated compounds are well documented for their carcinogenic property, reproductive, neuro, hepato and developmental toxicities. Diallyl disulfide (DADS), a garlic organosulfur compound exerts its effect as a chemopreventive agent via the modulation of drug metabolizing enzymes which has led us to hypothesize that DADS could ameliorate the PCB-induced toxicity in liver and ventral prostate of the rats. In the present investigation, experimentally induced PCB toxicity elevated the activities of phase I enzymes and lipid peroxides level, whereas lowered the levels of phase II enzymes. Oral administration of DADS for 7 days modulated the levels of drug metabolizing enzymes and reduced the lipid peroxides level. These results suggest that PCBs can be readily metabolized by DADS administration through enhancing phase II enzymes thereby it reduces the toxic effects.
关键词：diallyl disulfide;polychlorinated biphenyls;drug metabolizing enzymes;cytochrome P450s;glutathione-S-transferase