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  • 标题:酵素法によるオリゴ糖鎖ライブラリーの構築
  • 本地全文:下载
  • 作者:村田 健臣 ; 碓氷 泰市
  • 期刊名称:Journal of Applied Glycoscience
  • 印刷版ISSN:1344-7882
  • 电子版ISSN:1880-7291
  • 出版年度:2000
  • 卷号:47
  • 期号:2
  • 页码:253-260
  • DOI:10.5458/jag.47.253
  • 出版社:The Japanese Society of Applied Glycoscience
  • 摘要:

    With the growing biological importance of oligosaccharides involved in glycoconjugates, practical synthetic methods for obtaining oligosaccharides have been required. Enzyme-catalyzed oligosaccharide synthesis has been shown to be one of the most effective methods for large-scale oligo-saccharide synthesis. This review describes enzyme-catalyzed synthesis of di, tri, and tetrasaccharide units, which are related to biological roles: (1) galactose-containing disaccharides, (2) fucosecontaining trisaccharides, (3) core oligosaccharides in mucin-type carbohydrate, and (4) human milk oligosaccharides. Such well-defined oligosaccharide units are useful as substrates for glycosidases and glycosyltransferases, and as starting materials for artificial glycopolymers, which are valuable as probes of carbohydrate-protein interaction.

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