文章基本信息

标题：Transcriptional Features of Cattle Visceral and Subcutaneous Adipose Tissues: A Study of RNA-seq
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作者：Xiaoyan Duan ; Yu Liu ; Xiaoxiao Zhang 等
期刊名称：Open Journal of Animal Sciences
印刷版ISSN：2161-7597
电子版ISSN：2161-7627
出版年度：2022
卷号：12
期号：3
页码：441-453
DOI：10.4236/ojas.2022.123033
语种：English
出版社：Scientific Research Pub
摘要：Visceral and subcutaneous are the two major types of bovine adipose tissues, and they show metabolic and functional differences according to their distribution, exploring the transcriptional features of visceral and subcutaneous adipose tissues is necessary. In the present study, we conducted RNA-seq analysis to compare the transcriptome between visceral (great omental) and subcutaneous (backfat) adipose tissues from Chinese Simmental cattle and validate them by qRT-PCR. We found that 5864 genes were differentially expressed between two tissues, including 2979 up-regulated and 2885 down-regulated in visceral adipose tissue. Functional analysis revealed a variety of differentially expressed genes (DEGs) involved in lipid metabolism and immune response processes. This may provide valuable information to further our understanding of the complexity of gene regulation governing the physiology of different fat depots. This work highlighted potential genes regulating lipid metabolism and immune responses; it may contribute to a better understanding of the metabolic and functional differences between visceral and subcutaneous adipose tissues.
关键词：Visceral Adipose TissueSubcutaneous Adipose TissueTranscriptional FeaturesCattle