文章基本信息

标题：Host-Microbiota Co-immunity: An Intimate Relationship That Goes Beyond Protection
本地全文：下载
作者：Thomas Bazin orcid logo ; Lynn Chiu orcid logo ; Thomas Pradeu 等
期刊名称：Philosophy, Theory, and Practice in Biology
电子版ISSN：2475-3025
出版年度：2022
卷号：14
DOI：10.3998/ptpbio.2097
语种：English
出版社：Michigan Publishing
摘要：Resident microorganisms, known as the microbiota, are essential for many physiological functions including protection against pathogens. Microbiota is indeed required for proper immune system development and function, and can also host-independently protect against infections. Thus, a co-constructed view of host protection involving both host and microbiota, named "co-immunity," has been proposed, and the idea of an "immunological holobiont" has been suggested. Yet this view of co-immunity might be too limited, as experimental work has shown that the immune system is involved in functions other than protection, essentially development and repair. Microbiota, through co-immunity, is thereby most likely involved in these functions, although strong evidence is currently lacking. Moreover, as our point of view is mainly host-centered, we may miss the implications of co-immunity at broader scales, including cellular and population levels. Intriguingly, co-immunity effects could be beneficial for one function and/or one level, while being detrimental for others. All these elements should be taken into consideration for microbiota manipulation, in order to avoid potentially harmful side effects.
关键词：individuality;immunity;tissue repair;symbiosis;microbial ecology;colonization resistance;disease tolerance;containment