文章基本信息

标题：Status of Inflammatory Biomarkers in the Population that Survived the Bhopal Gas Tragedy: A Study after Two Decades
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作者：Arpit BHARGAVA ; Ram Prakash PUNDE ; Neelam PATHAK 等
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：2010
卷号：48
期号：2
页码：204-208
DOI：10.2486/indhealth.48.204
出版社：National Institute of Occupational Safety and Health
摘要：Bhopal gas tragedy is considered as one of the world's worst industrial disaster. Approximately, 3,000-6,000 people died and 200,000 injured due to the leak of 40 tons of methyl isocyanate (MIC) gas from a pesticide plant. We aimed to decipher any persistent and subtle immunotoxic effects of MIC in the survivors of the tragedy. The study was divided into 3 groups i.e. group I (n=40); Age and gender matched non-exposed healthy controls recruited from places within the geographical region of Bhopal but from unaffected zones, group II (n=40); Age and gender matched non-exposed healthy controls recruited from places well outside geographical region of Bhopal and group III (n=40); Age and gender matched MIC exposed subjects from affected zones inside geographical region of Bhopal and the status of inflammatory biomarkers (IL-8, IL-1 β , IL-6, TNF, IL-10, IL-12p70 cytokines and C-reactive protein) were analysed. The results displayed a significant increase in the levels of all circulating inflammatory biomarkers in the MIC exposed group in comparison to non-exposed cohorts. A toxin induced genetic and/or epigenetic alteration seems to be the likely underlying cause. However, further studies are essential for both mechanistic understanding and clinical implications of these patterns.
关键词：Methyl isocyanate;Bhopal gas tragedy;Immunotoxicity;Inflammation;Biomarkers