文章基本信息

标题：Individual Susceptibility to Cadmium Toxicity and Metallothionein Gene Polymorphisms: with References to Current Status of Occupational Cadmium Exposure
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作者：Nobuhiko MIURA
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：2009
卷号：47
期号：5
页码：487-494
DOI：10.2486/indhealth.47.487
出版社：National Institute of Occupational Safety and Health
摘要：The incidence of serious poisoning caused by occupational cadmium exposure has declined over the past four decades due to improvements in the work environment. However, long-term low-level exposure to cadmium needs to be addressed. For workers in industries that handle cadmium, it is necessary to consider the daily cadmium intake from contaminated foods such as cereals and rice in addition to the occupational exposure, since workers might be exposed to higher levels of cadmium from a combination of these sources. Cadmium accumulates in the renal cortex by the long-term exposure along with increased concentrations of metallothionein, an important protein for protection from cadmium toxicity. However, some individuals have lower metallothionein levels despite increased cadmium accumulation in the kidneys. This article describes the strategy method for analyzing individual susceptibility to cadmium toxicity and genetic polymorphisms of metallothionein, with reference to the current status of occupational cadmium exposure.
关键词：Cadmium;Occupational exposure;Metallothionein;Polymorphism