文章基本信息

标题：Individual Susceptibility to Occupational Contact Dermatitis
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作者：Sanja KEZIC ; Maaike J. VISSER ; Maarten M. VERBERK 等
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：2009
卷号：47
期号：5
页码：469-478
DOI：10.2486/indhealth.47.469
出版社：National Institute of Occupational Safety and Health
摘要：Occupational Contact Dermatitis (OCD) is one of the most common work-related diseases. High risk occupations are in health care, hairdressing, food sector and metal industry. OCD tends to become chronic; persistent OCD often results in impaired quality of life and loss of work ability. The purpose of this article is to review the present knowledge on the factors which determine individual susceptibility to acquire OCD. Recent discoveries regarding genes involved in the skin barrier, inflammatory response and biotransformation of xenobiotics provide more insight in the individual susceptibility for OCD. Knowledge of the factors which predispose to OCD is useful in occupational health practice for the application of preventive measures and for career guidance for apprentices and workers in high risk occupations.
关键词：Susceptibility;Contact dermatitis;Occupational;Filaggrin;Cytokines;Genetic polymorphisms;Skin barrier;Atopy