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标题：Early Biochemical Alterations in Manganese Toxicity: Ameliorating Effects of Magnesium Nitrate and Vitamins
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作者：Shakeel ZAIDI ; Ashwin PATEL ; Nilesh MEHTA 等
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：2005
卷号：43
期号：4
页码：663-668
DOI：10.2486/indhealth.43.663
出版社：National Institute of Occupational Safety and Health
摘要：Manganese-induced early biochemical changes and effects of supplementation of magnesium nitrate (Mg(NO₃)₂) and antioxidant vitamins (A, C, D and E) were studied in rats intoxicated with manganese. Significant elevation in the level of chlorides in plasma, erythrocytes, liver and cerebellum, and a decrease in plasma inorganic phosphate (pi) with an increase in liver pi were observed in animals exposed to manganese as compared to controls. The level of erythrocyteacid labile phosphate (ALP), nicotinamide adeninedinucleotide (NAD⁺) and plasma sialic acid (N-acetylneuraminic acid, NANA) also increased significantly. Elevated levels of chlorides in plasma, erythrocytes and cerebellum reversed to normal control values whereas liver chlorides restored partially by the supplementation of Mg(NO₃)₂. Vitamins supplementation was effective to reverse chlorides level in erythrocytes, liver and cerebellum. Decreased level of pi in plasma and the highly elevated level of erythrocyte ALP were also recovered in animals received Mg(NO₃)₂ in addition to MnSO₄. However, such effect of Mg(NO₃)₂ was not seen in lowering the elevated level of NANA that restored by the administration of vitamins. Thus, the early alterations in plasma levels of chlorides, pi, and NANA and erythrocyte-ALP seem to be an indicative of early manganese toxicity while Mg(NO₃)₂ and vitamins supplementation appear to provide, at least in part, protection against manganese toxicity.
关键词：Biochemical alterations;Manganese toxicity;Ameliorating effects;Magnesium nitrate;Antioxidant vitamins