文章基本信息

标题：Simultaneous Determination of 8-hydroxydeoxyguanosine, a Marker of Oxidative Stress, and Creatinine, a Standardization Compound, in Urine
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作者：Hiroshi KASAI ; Peter SVOBODA ; Sayumi YAMASAKI 等
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：2005
卷号：43
期号：2
页码：333-336
DOI：10.2486/indhealth.43.333
出版社：National Institute of Occupational Safety and Health
摘要：Recently, H. Kasai reported an automatic, precise method of 8-hydroxydeoxyguanosine (8-OH-dG) analysis in urine by high performance liquid chromatography coupled to an electrochemical detector (HPLC-ECD). It is based on a cleaning-up step by anion-exchange chromatography and a further purification step using reverse phase chromatography before detection by the ECD. In this communication, we report a method for the simultaneous determination of 8-OH-dG and creatinine, an internal standard for normalizing the excretion of 8-OH-dG in urine.
关键词：8-hydroxydeoxyguanosine;Creatinine;Urine