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标题：Two-Week Oral Toxicity Study of 1,4-Dichloro-2-Nitrobenzene in Rats and Mice
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作者：Kazunori YAMAZAKI ; Makoto OHNISHI ; Shigetoshi AISO 等
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：2005
卷号：43
期号：2
页码：308-319
DOI：10.2486/indhealth.43.308
出版社：National Institute of Occupational Safety and Health
摘要：Subacute toxicity of 1,4-dichloro-2-nitrobenzene (DCNB) was examined by feeding F344 rats and BDF₁ mice of both sexes a diet containing DCNB at 625, 1,250, 2,500, 5,000 or 10,000 ppm (w/w) for 2 weeks. All DCNB-fed rats survived to the end of the 2-week administration period, but 2 male and 6 female mice fed 10,000 ppm died during this period. The subacute toxicity was characterized by lesions affecting the liver, kidney, testis and hematopoietic system. The liver was the most responsive to DCNB, as evidenced by a dose-related increase in relative liver weight in rats and mice and centrilobular hypertrophy of hepatocytes in mice. An alteration in liver-associated lipid metabolism was suggested from the concomitant increases in serum concentrations of total cholesterol and phospholipid. A lower confidence limit of the benchmark dose yielding the response with 10% extra risk (BMDL₁₀) for the relative liver weight indicated that rats were more responsive to DCNB than mice. The kidney lesion was characterized by α_2υ-globulin-accumulated hyaline droplets in the renal tubular epithelial cells only in male rats, as indicated by positive anti-α_2υ-globulin immunohistochemical staining. Testicular and hematopoietic lesions appeared at higher dose levels than did the liver and kidney lesions.
关键词：Rats;Mice;1,4-Dichloro-2-nitrobenzene;Liver;Kidney;Reproductive toxicity;Hepatocellular hypertrophy;Hematopoiesis;α2υ-globulin