文章基本信息

标题：Recent Advances in Single-Molecule Sensors Based on STM Break Junction Measurements
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作者：Shan-Ling Lv ; Cong Zeng ; Zhou Yu 等
期刊名称：Biosensors
电子版ISSN：2079-6374
出版年度：2022
卷号：12
期号：8
DOI：10.3390/bios12080565
语种：English
出版社：MDPI Publishing
摘要：Single-molecule recognition and detection with the highest resolution measurement has been one of the ultimate goals in science and engineering. Break junction techniques, originally developed to measure single-molecule conductance, recently have also been proven to have the capacity for the label-free exploration of single-molecule physics and chemistry, which paves a new way for single-molecule detection with high temporal resolution. In this review, we outline the primary advances and potential of the STM break junction technique for qualitative identification and quantitative detection at a single-molecule level. The principles of operation of these single-molecule electrical sensing mainly in three regimes, ion, environmental pH and genetic material detection, are summarized. It clearly proves that the single-molecule electrical measurements with break junction techniques show a promising perspective for designing a simple, label-free and nondestructive electrical sensor with ultrahigh sensitivity and excellent selectivity.
关键词：single-molecule sensor;STM break junction;ionic detection;pH detection;nucleotide detection