文章基本信息

标题：Stimulatory effects of collagen production induced by coenzyme Q 10 in cultured skin fibroblasts
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作者：Yukitoshi Mine ; Takayuki Takahashi ; Tadashi Okamoto 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2022
卷号：71
期号：1
页码：29-33
DOI：10.3164/jcbn.20-187
语种：English
出版社：The Society for Free Radical Research Japan
摘要：Coenzyme Q 10 (CoQ 10) is a well-known antioxidant and serves as an essential carrier for electron transport and proton translocation in the mitochondrial respiratory chain. CoQ 10 has been widely commercially available in Japan as a dietary and health supplement since 2001 and it is used for the prevention of lifestyle-related diseases induced by aging. Recently, it was stated that for Japan, which is facing an aging society, CoQ 10 has been used in many skincare products. However, the physiological actions of CoQ 10 in skin fibroblasts are not fully understood. In this study, we examined the effect of CoQ 10 on cultured human skin fibroblast. In this study, CoQ 10 treatment increased intracellular CoQ 10 level and promoted proliferation of fibroblasts. In addition, CoQ 10 increased mRNA expression of type I, IV, VII collagen, elastin, and HSP47, whereas CoQ 10 has little effect on mRNA of type II and VIII MMP. These results suggested that CoQ 10 has the efficacy that it increases collagen production in skin, thereby there is possible of the anti-aging by CoQ 10 in Japan which reached an aging society, so that it might be based on new physiological function by CoQ 10.
关键词：coenzyme Q10;collagen;anti-aging;fibroblasts;elastin