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标题：Omega-9 Modifies Viscoelasticity and Augments Bone Strength and Architecture in a High-Fat Diet-Fed Murine Model
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作者：Mahmoud Omer ; Hessein Ali ; Nina Orlovskaya 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2022
卷号：14
期号：15
DOI：10.3390/nu14153165
语种：English
出版社：MDPI Publishing
摘要：The influence of diet on the development of osteoporosis is significant and not fully understood. This study investigated the effect of diets of varying lipid profiles and ω-3, ω-6 and ω-9 composition on the structural and mechanical properties of bone. The hypothesis studied was that a diet high in saturated fat would induce osteoporosis and produce an overall increased detrimental bony response when compared with a diet high in unsaturated ω-6, or ω-9. Male C57BL/6J mice were fed either a control diet, 50:50 mix (saturated:unsaturated) high in ω-9 (HFD 50:50), a diet high in saturated fat (HSF) or a polyunsaturated fat diet high in ω-6 (PUFA) over an 8-week duration. Tibiae were retrieved and evaluated using DMA, 3-point-bending, histomorphometry, and microCT. Mice fed a HSF diet displayed key features characteristic of osteoporosis. The loss tangent was significantly increased in the HFD 50:50 diet group compared with control ( p = 0.016) and PUFA-fed animals ( p = 0.049). HFD 50:50-fed mice presented with an increased viscous component, longer tibiae, increased loss modulus ( p = 0.009), and ultimate stress, smaller microcracks ( p < 0.001), and increased trabecular width ( p = 0.002) compared with control animals. A diet high in ω-9 resulted in an overall superior bone response and further analysis of its role in bone health is warranted.
关键词：enosteoporosissaturated fatspolyunsaturated fatsmonounsaturatedbone strengthviscoelasticity