文章基本信息

标题：Effects of Artichoke Supplementation on Liver Enzymes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
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作者：Mohammad Reza Amini ; Fatemeh Sheikhhossein ; Alireza Talebyan 等
期刊名称：Clinical Nutrition Research
印刷版ISSN：2287-3732
出版年度：2022
卷号：11
期号：3
页码：228-239
DOI：10.7762/cnr.2022.11.3.228
语种：English
出版社：KoreaMed Synapse
摘要：Studies examining the effect of artichoke on liver enzymes have reported inconsistent results. This systematic review and meta-analysis aimed to assess the effects of artichoke administration on the liver enzymes. PubMed, Embase, the Cochrane Library, and Scopus databases were searched for articles published up to January 2022. Standardized mean difference (Hedges’ g) were analyzed using a random-effects model. Heterogeneity, publication bias, and sensitivity analysis were assessed for the liver enzymes. Pooled analysis of seven randomized controlled trials (RCTs) suggested that the artichoke administration has an effect on both alanine aminotransferase (ALT) (Hedges’ g, −1.08; 95% confidence interval [CI], −1.76 to −0.40; p = 0.002), and aspartate aminotransferase (AST) (Hedges’ g, −1.02; 95% CI, −1.76 to −0.28; p = 0.007). Greater effects on ALT were detected in trials that lasted ≤8 weeks. Also, greater effects on AST were detected in trials using > 500 mg artichoke. Overall, this meta-analysis demonstrated artichoke supplementation decreased ALT and AST.
关键词：Artichoke;Liver enzymes;Alanine aminotransferase;Aspartate aminotransferase