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标题：ASSESSMENT OF BIOMARKERS OF ORTHODONTIC TOOTH MOVEMENT WITH FIXED APPLIANCES-ORIGINAL RESEARCH
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作者：Amit Bhardwaj ; Kamal D Hotchandani ; Vivek Chaudhary 等
期刊名称：International Journal of Early Childhood Special Education
电子版ISSN：1308-5581
出版年度：2022
卷号：14
期号：5
页码：5230-5233
DOI：10.9756/INTJECSE/V14I5.636
语种：English
出版社：International Journal of Early Childhood Special Education
摘要：Background: Several important biomarkers have been identified clinically and in animal studies that mediate orthodontic tooth movement. The present study was conducted to assess biomarkers of orthodontics. Materials & Methods: 28 patients requiring orthodontic treatment of both genders were divided into 2 groups of 14 each. Group I was vibrational and fixed appliance group and group II was fixed appliance group only. Collection of unstimulated whole saliva in a sterile test tube was done and the targeted biomarkers such as IL1b and IL18 were analyzed using ELISA assay test. Results: Group I had 5 males and 9 females and group II had 6 males and 8 females. Irregularity index at time point T0 was 8.4 in group I and 9.6 in group II, at T1 was 5.2 in group I and 5.7 in group II, at T2 was 2.1 in group I and 2.3 in group II and at T3 was 1.0 in group I and 0.8 in group II. The difference was significant (P< 0.05). The mean pain score value at T0 was 40.2 in group I and 34.2 in group II, at T1 was 16. 5 in group I and 14.5 in group II and at T2 was 28.1 in group I and 40.7 in group II. The difference was significant (P< 0.05). The mean IL- IB level at T0 was 41.5 and 82.5, at T1 was 26.3 and 57.4, at T2 was 29.7 and 106.3 and at T3 was 26.8 and 131.5. The mean IL- 8 level at T0 was 265.4 and 250.5, at T1 was 190.7 and 178.2, at T2 was 198.2 and 261.5 and at T3 was 296.4 and 385.2 in group I and II respectively. The difference was significant (P< 0.05). Conclusion: There was no difference in the expression of biological markers of bone remodeling between both groups.
关键词：biological markers;orthodontics;IL- 8