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标题：Electrical resistance during blood coagulation – A pilot study
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作者：Hemashree L ; Vani Krishna Murthy ; Srinivasa Murthy Doreswamy 等
期刊名称：International Journal of Early Childhood Special Education
电子版ISSN：1308-5581
出版年度：2022
卷号：14
期号：3
页码：1668-1674
DOI：10.9756/INT-JECSE/V14I3.195
语种：English
出版社：International Journal of Early Childhood Special Education
摘要：Deranged blood coagulation leads to uncontrolled bleeding and blood loss resulting in hypovolemic shock.Identification of such altered coagulation state is of at most importance for sick patients receiving intensive care treatment. Currently, laboratories used elaborative enzymatic methods for identifying changes in mechanical or optical properties of plasma and not the whole blood. These tests typically take about an hour to be reported. Other point of care coagulometer using viscoelastic principle applied to whole blood is too expensive.Several studies have been conducted in a non-clinical environment and have shown the change in the electrical properties of the blood during the process of coagulation. The advantages of using electrical principles include a small form factor, ubiquity of use and not needing technical expertise for use. Method: A purpose-built device studied under various clinical conditions could serve as a proof of concept for the further development of precise medical-grade devices for clinical use. A purpose-built device working on the potential divider principle and a gold-plated electrode was tested in this pilot study using 32 clinical samples. Result: The average difference between the electrical resistance before and after coagulation was 5178 ohms which were statistically significant.The median (interquartile range) of time taken to the first peak of uncoagulated blood was 565 (470 – 594) seconds. The time is taken after coagulation was 333 (73 – 558) seconds. The median difference was not statistically significant with a p-value of 0.149. The rate of ascent to the first peak denoted as dr/dt of uncoagulated blood was 34 (29 – 60) ohms/sec. The rate of ascent after coagulation was 45 (40 - 82) ohms/sec. The median difference was statistically significant with a p-value of 0.039. Conclusion: Coagulation status can be assessed using the electrical properties of the blood.
关键词：Human blood;electrical resistance;coagulation