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标题：QUENCHING OF QUORUM SENSING REGULATED PROTEINS OF NOSOCOMIAL P. AERUGINOSA BY IN SILICO APPROACH
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作者：G. Jayalakshmi ; C. Naveen Kumar ; R. Srikumar 等
期刊名称：International Journal of Early Childhood Special Education
电子版ISSN：1308-5581
出版年度：2022
卷号：14
期号：2
页码：4373-4381
DOI：10.9756/INT-JECSE/V14I2.479
语种：English
出版社：International Journal of Early Childhood Special Education
摘要：Quorum sensing is the cell to cell communication mechanism in microorganism through signalling molecules. Pseudomonas aeruginosa is an opportunistic pathogenand well known for its nosocomial infection and multi-drug resistance (MDR).P. aeroginosa uses quorum sensing system to regulate their co-operative phenotypic behaviours like biofilm formation, virulence factor etc.,Las and Rhl are acyl homoserine lactone(AHL) based QS systems present in P.aerginosa and the Las system comprised of the transcriptional factor called LasR which can activate the expression of target virulence gene. Thus the pathogenic activity of in P.aerginosacan be repressed by restraining the target protein, LasR with suitable bioactive molecules. In the present study, bioactive compounds from various natural food sources have been selected and tested against LasR protein using bioinformatics tools for its quorum quenching activity. In silico analysis gave prominent results for thirteen compounds out of 25 compounds tested with best docking score. These selected for compounds can be suggested for in vitro and in vivo studies and could be used for QSI based drugs against P.aerginosa infections.
关键词：Quorum Sensing Inhibitors (QSI);P. aerginosa;Nosocomial infection;Molecular Docking;Bioactive compounds