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标题：AN INSILICO APPROACH TOWARDS IDENTIFICATION OF VIRULENCE FACTORS IN FUSOBACTERIUM NUCLEATUM TARGETED BY TRICLOSAN
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作者：Induja.M.P ; Arvina Rajasekar
期刊名称：International Journal of Early Childhood Special Education
电子版ISSN：1308-5581
出版年度：2022
卷号：14
期号：1
页码：2896-2902
DOI：10.9756/INT-JECSE/V14I1.348
语种：English
出版社：International Journal of Early Childhood Special Education
摘要：Background: Fusobacterium nucleatum is a periodontal pathogen and an anaerobic oral commensal that has been linked to a variety of human disorders. Triclosan has been used in toothpastes, cosmetics and antiseptic soaps which are all examples of antibacterial and antifungal agents. The aim of this study was to identify the virulence factors in Fusobacterium nucleatum targeted by triclosan through an insilico approach. Materials and Methods: The STITCH v.5 pipeline12 was used to investigate drug interactions with the proteome of Fusobacterium nucleatum. VirulentPred and VICMPred were utilised to determine the virulence characteristic and functional class of the proteins using the pipeline. Results: Fusobacterium nucleatum interact with proteins which involved in cellular processes, metabolism and pathogenicity were discovered to interact with it. Conclusion: A thorough understanding of the interactions between these medications and their antibacterial agents would increase the list of advantages these treatments have in therapeutic situations. To validate the true interactions between medicines and pathogen protein repertoires, more in vitro study on a wide spectrum of infections is required.
关键词：Fusobacterium nucleatum;Triclosan;Proteins