文章基本信息

标题：Polyunsaturated Fatty Acid-Derived Lipid Mediators That Regulate Epithelial Homeostasis
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作者：Tatsuro Naganuma ; Nodoka Fujinami ; Makoto Arita 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2022
卷号：45
期号：8
页码：998-1007
DOI：10.1248/bpb.b22-00252
语种：English
出版社：The Pharmaceutical Society of Japan
摘要：Epithelial tissues are mainly composed of epithelial cells, covering both internal and external surfaces of our body. To maintain epithelial homeostasis, cellular functions, such as proliferation, migration, and differentiation, are flexibly regulated in response to changes in the cellular status, thereby contributing to barrier formation, immune reaction, and wound closure. Polyunsaturated fatty acids (PUFAs) are precursors of various lipid mediators that maintain tissue homeostasis by exerting characteristic bioactivities. This review aimed to summarize the role of PUFA-derived lipid mediators in epithelial cell functions, mainly focusing on the epidermis, cornea, and intestinal epithelium.
关键词：polyunsaturated fatty acid;lipid mediator;epithelium