文章基本信息

标题：In Vitro Production of Optically Active Octahydrocurcumin by Human Intestinal Bacterium
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作者：Toshio Niwa ; Shin-ichiro Yokoyama ; Mika Mochizuki 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2022
卷号：45
期号：3
页码：378-381
DOI：10.1248/bpb.b21-00992
语种：English
出版社：The Pharmaceutical Society of Japan
摘要：Enterococcus avium, producing 5R-hexahydrocurcumin metabolized tetrahydrocurcumin to octahydrocurcumin in vitro. Based on a detailed analysis of the two secondary alcohols, the metabolite obtained from tetrahydrocurcumin via 5R-hexahydrocurcumin was identified as 3R,5R-octahydrocurcumin. The activities of 5R-hexahydrocurcumin and 3R,5R-octahydrocurcumin were compared to those of the synthetic compounds, using monocyte chemoattractant protein-1 produced via murine adipocytes in vitro. The optically active curcuminoids reduced the cytokine production similar to tetrahydrocurcumin without any difference in their stereochemistry.
关键词：curcumin;hexahydrocurcumin;octahydrocurcumin;metabolism;microflora