文章基本信息

标题：Regulatory Roles of N- and C-Terminal Cytoplasmic Regions of P4-ATPases
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作者：Hye-Won Shin ; Hiroyuki Takatsu
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2022
卷号：70
期号：8
页码：524-532
DOI：10.1248/cpb.c22-00042
语种：English
出版社：The Pharmaceutical Society of Japan
摘要：P4-ATPases, which are subfamily members of P-type ATPase superfamily, translocate membrane lipids from the exoplasmic/luminal leaflet to the cytoplasmic leaflet, thus regulating trans-bilayer lipid asymmetry. Mammalian P4-ATPases localize to the specific subcellular organelles or the plasma membrane where they translocate the specific lipids. Although recent advances in the structural analysis of P4-ATPases have improved our understanding of lipid transporting machinery, the mechanism of substrate specificity and the regulatory mechanism of the enzymes remain largely unknown. Recent studies have uncovered several specific localization and regulatory mechanisms of P4-ATPases. Here, we review the current understanding of the regulatory mechanism of P4-ATPase activity and localization in mammalian cells.
关键词：lipid bilayer;lipid asymmetry;P4-ATPase;flippase