文章基本信息

标题：Rewriting the Central Dogma with Synthetic Genetic Polymers
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作者：Noriko Saito-Tarashima ; Akiho Murai ; Noriaki Minakawa 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2022
卷号：70
期号：5
页码：310-315
DOI：10.1248/cpb.c21-00960
语种：English
出版社：The Pharmaceutical Society of Japan
摘要：DNA and RNA are ubiquitous molecules responsible for storage and transmission of genetic information and together comprise the central dogma of molecular biology. However, the recent emergence of synthetic genetic polymers is providing an opportunity to challenge the fundamental principles of life. Herein, we describe the ongoing attempts to rewrite the central dogma with 4′-thioDNA and 4′-thioRNA, which feature a sulfur instead of an oxygen atom in the furanose ring moiety. Using reconstituted Escherichia coli gene expression machinery, studies have shown that the genetic information conserved in 4′-thioDNA can be transcribed to 4′-thioRNA and eventually translated into protein, mirroring the processes that occur in nature. Such studies underscore the feasibility of controlling life by substances other than DNA and RNA.
关键词：4′-thioDNA;4′-thioRNA;4′-thionucleotide;synthetic biology;oligonucleotide;central dogma