文章基本信息

标题：Sulfated Naphthopyrones and Anthraquinones from the Vietnamese Crinoid Comanthus delicata
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作者：Le Thi Vien ; Tran Thi Hong Hanh ; Tran Hong Quang 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2022
卷号：70
期号：5
页码：408-412
DOI：10.1248/cpb.c21-00904
语种：English
出版社：The Pharmaceutical Society of Japan
摘要：Three new sulfated naphthopyrone derivatives namely delicapyrons F–H (1–3) and two new sulfated anthraquinone derivatives namely delicaquinons A (4) and B (5), together with 6-methoxycomaparvin-5-methylether-8-O-sodium sulfate (6), 6-methoxycomaparvin-8-O-sodium sulfate (7), comaparvin-8-O-sodium sulfate (8), and 3-propyl-1,6,8-trihydroxy-9,10-anthraquinone-6-O-sodium sulfate (9) were isolated from the Vietnamese crinoid Comanthus delicata. Their chemical structures were elucidated by extensive analysis of the one dimensional (1D) and 2D-NMR, high resolution electrospray ionization quadrupole time-of-flight (HR-ESI-QTOF) mass spectra as well as calculation of optical rotation. In addition, significant cytotoxicity was observed for 6 against LNCaP (prostate cancer) cell line with IC50 value of 20.29 ± 2.43 µM, whereas moderate or weak cytotoxic effects were observed for 1–3 and 5–8 on SK-Mel-2 (melanoma) cell line and 7 and 8 against LNCaP cell line, with IC50 values ranging from 49.96 ± 1.74 to 76.92 ± 5.85 µM.
关键词：Comanthus delicata;crinoid;sulfated naphthopyrone;sulfated anthraquinone;cytotoxic activity