文章基本信息

标题：Transport Characteristics of Placenta-Derived Extracellular Vesicles and Their Relevance to Placenta-to-Maternal Tissue Communication
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作者：Mai Inagaki ; Masanori Tachikawa
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2022
卷号：70
期号：5
页码：324-329
DOI：10.1248/cpb.c22-00072
语种：English
出版社：The Pharmaceutical Society of Japan
摘要：The placenta, a unique organ that helps maintain a healthy pregnancy, plays a pivotal role in maternal adaptation to pregnancy and releases extracellular vesicles (EVs), autacoids, and hormones. EVs are membranous vesicles released by all types of cells, including placental trophoblasts, which are involved in intracellular communication by delivering their cargo, such as proteins, nucleic acids, and lipids, to the targeted cells in a neighboring or distant location. Recently, an increasing number of publications have reported that EVs secreted from the placenta into maternal circulation deliver their cargo to maternal organs and mediate placenta-to-maternal communication during pregnancy. This review provides an overview of the transport mechanism of placenta-derived EVs to maternal organs.
关键词：placenta;extracellular vesicle;transport mechanism