文章基本信息

标题：Semisynthesis of Antitrypanosomal p-Quinone Analog Possesing the Komaroviquinone Pharmacophore
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作者：Yutaka Aoyagi ; Koji Fujiwara ; Yoshinao Takahashi 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2022
卷号：70
期号：4
页码：300-303
DOI：10.1248/cpb.c21-00998
语种：English
出版社：The Pharmaceutical Society of Japan
摘要：A p-quinone analog having the komaroviquinone pharmacophore fused with a more conformationally flexible cycloheptane ring, was semisynthesized from natural demethlsalvicanol isolated from Perovskia abrotanoides via four steps in 26% overall yield. The IC50 for the antitrypanosomal activity of the analog was 0.55 µM.
关键词：semisynthesis;demethylsalvicanol;antitrypanosomal activity;komaroviquinone analog;Perovskia abrotanoides