文章基本信息

标题：Chemical Synthesis and Evaluation of Exopolysaccharide Fragments Produced by Leuconostoc mesenteroides Strain NTM048
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作者：Shinsuke Inuki ; Hitomi Tabuchi ; Chiaki Matsuzaki 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2022
卷号：70
期号：2
页码：155-161
DOI：10.1248/cpb.c21-00919
语种：English
出版社：The Pharmaceutical Society of Japan
摘要：Exopolysaccharides (EPSs) occur widely in natural products made by bacteria, fungi and algae. Some EPSs have intriguing biological properties such as anticancer and immunomodulatory activities. Our group has recently found that EPSs generated from Leuconostoc mesenteroides ssp. mesenteroides strain NTM048 (NTM048 EPS) enhanced a production of mucosal immunoglobulin A (IgA) of mouse. Herein, we described the synthesis and evaluation of the tetrasaccharide fragments of NTM048 EPS to obtain information about the molecular mechanism responsible for the IgA-inducing activity.
关键词：exopolysaccharide;Leuconostoc mesenteroides;glycosylation;fragment synthesis;immunomodulatory activity