文章基本信息

标题：Roles of BMP6/7 in Actin Dynamics in Amyloid β-Induced Neurotoxicity
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作者：Lin Sun ; Yingjie Zhang ; Shifu Xiao 等
期刊名称：Psychology
印刷版ISSN：2152-7180
电子版ISSN：2152-7199
出版年度：2014
卷号：05
期号：07
页码：707-717
DOI：10.4236/psych.2014.57082
语种：English
出版社：Scientific Research Publishing
摘要：Actin dynamics plays an important role in many physiological functions such as long-term potentiation, neurotransmission, regulatory proteins translocation, ATP cycle, etc. When amyloid β (Aβ)-induced neurotoxicity occurs, the imbalance of actin dynamics leads to dystrophy of dendrites, which is characteristic pathology in Alzheimer’s disease (AD). Transient and persistent Aβ neurotoxicity provokes distinct manifestations of actin dynamics and causes opposing effects in AD. It has been shown that bone morphogenetic protein 6/7 (BMP6/7) protects neuronal morphology against Aβ-induced neurotoxicity, and can directly bind to LIM kinase1 (LIMK1), being one part of the upstream regulatory pathway of actin dynamics. This review aims to discuss a potential mechanism of BMPs underlying maintainance of cytoskeletal stabilization in neurite.
关键词：Amyloid β; BMP; Actin Dynamics; LIMK1; Alzheimer’s Disease