文章基本信息

标题：Using Individual, ApoE Genotype-Based Dietary and Physical Activity Advice to Promote Healthy Lifestyles in Finland—Impacts on Cardiovascular Risk Markers
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作者：Hanna-Leena Hietaranta-Luoma 1* , Kari Åkerman 2 , Raija Tahvonen 3 , Hannu Puolijoki 2 , Anu Hopia
期刊名称：Open Journal of Preventive Medicine
印刷版ISSN：2162-2477
电子版ISSN：2162-2485
出版年度：2015
卷号：05
期号：05
页码：206-217
DOI：10.4236/ojpm.2015.55024
语种：English
出版社：Scientific Research Publishing
摘要：Aim: There is increasing demand for individualized health advice. The aim of this study was to assess the effects on cardiovascular risk markers of receiving personal genetic health information, using apoE genotypes as a tool for promoting lifestyle changes. ApoE was chosen because it had a significant impact on lipid metabolism and cholesterol absorption, all factors for CVD. Methods: This study was a one-year explanatory intervention study for healthy adults, aged between 20 - 67 years old (n = 106). Their clinical markers (serum lipids, blood glucose, blood pressure, Body Mass Index, body fat percentage and waist circumference) were measured three times during the intervention. The clinical effects were assessed for three groups: a high risk group (ε 4+, n = 16); a low-risk group (&949 4-, n = 35); and a control group (n = 55). Results: The triglyceride values and waist circumference lowered more in &949 4+ compared with the control group (p < 0.05; alpha value 0.005) during the intervention. Conclusion: The personal genetic information, based on apoE, may have positive effects on cardiovascular risk markers (e.g., improvement in triglyceride values). The individual health information, based on genotyping could be a potential option in the prevention of CVD. More research is required on how to utilize genotype-based health information in the prevention of lifestyle-related diseases.
关键词：Genetic Information; ApoE; Intervention; Healthy Lifestyle; Cardiovascular Risk Markers