文章基本信息

标题：Artificial Gastrointestinal Models for Nutraceuticals Research—Achievements and Challenges: A Practical Review
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作者：Anna Gościniak ; Piotr Eder ; Jarosław Walkowiak 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2022
卷号：14
期号：13
DOI：10.3390/nu14132560
语种：English
出版社：MDPI Publishing
摘要：Imitating the human digestive system as closely as possible is the goal of modern science. The main reason is to find an alternative to expensive, risky and time-consuming clinical trials. Of particular interest are models that simulate the gut microbiome. This paper aims to characterize the human gut microbiome, highlight the importance of its contribution to disease, and present in vitro models that allow studying the microbiome outside the human body but under near-natural conditions. A review of studies using models SHIME, SIMGI, TIM-2, ECSIM, EnteroMix, and PolyfermS will provide an overview of the options available and the choice of a model that suits the researcher’s expectations with advantages and disadvantages.
关键词：enmicrobiomemicrobiotain vitro modelshuman gutnutraceuticals