文章基本信息

标题：Hericium erinaceus Mycelium Ameliorates In Vivo Progression of Osteoarthritis
本地全文：下载
作者：Shang-Yu Yang ; Chi-Jung Fang ; Yu-Wen Chen 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2022
卷号：14
期号：13
DOI：10.3390/nu14132605
语种：English
出版社：MDPI Publishing
摘要：Osteoarthritis (OA) is an age-related disorder that affects the joints and causes functional disability. Hericium erinaceus is a large edible mushroom with several known medicinal functions. However, the therapeutic effects of H. erinaceus in OA are unknown. In this study, data from Sprague-Dawley rats with knee OA induced by anterior cruciate ligament transection (ACLT) indicated that H. erinaceus mycelium improves ACLT-induced weight-bearing asymmetry and minimizes pain. ACLT-induced increases in articular cartilage degradation and bone erosion were significantly reduced by treatment with H. erinaceus mycelium. In addition, H. erinaceus mycelium reduced the synthesis of proinflammatory cytokines interleukin-1β and tumor necrosis factor-α in OA cartilage and synovium. H. erinaceus mycelium shows promise as a functional food in the treatment of OA.
关键词：enosteoarthritisHericium erinaceusmyceliumanterior cruciate ligament transectioninterleukin 1 betatumor necrosis factor-alpha