文章基本信息

标题：Passage of exogeneous fine particles from the lung into the brain in humans and animals
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作者：Yu Qi ; Shuting Wei ; Tao Xin 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2022
卷号：119
期号：26
DOI：10.1073/pnas.2117083119
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Significance Addressing the knowledge gaps regarding the access to and harmful effects of airborne fine particles on the central nervous system is critical. Various exogenous fine particles were found in human cerebrospinal fluids, including commonly found particles and others that have not been reported previously. Animal experiments provided mechanistic explanations and verifications of the translocation of inhaled particles into the brain. Moreover, retention of particles in the brain for longer durations than in other organs was demonstrated through isotope labeling–based biodistribution studies in mice, suggesting possible long-term effects on the brain. This work unravels indications and associations between inhalation and particle transport and adds evidence on the relationship between air pollution and detrimental effects of exogenous particles on the brain. There are still significant knowledge gaps in understanding the intrusion and retention of exogeneous particles into the central nervous system (CNS). Here, we uncovered various exogeneous fine particles in human cerebrospinal fluids (CSFs) and identified the ambient environmental or occupational exposure sources of these particles, including commonly found particles (e.g., Fe- and Ca-containing ones) and other compositions that have not been reported previously (such as malayaite and anatase TiO 2), by mapping their chemical and structural fingerprints. Furthermore, using mouse and in vitro models, we unveiled a possible translocation pathway of various inhaled fine particles from the lung to the brain through blood circulation (via dedicated biodistribution and mechanistic studies). Importantly, with the aid of isotope labeling, we obtained the retention kinetics of inhaled fine particles in mice, indicating a much slower clearance rate of localized exogenous particles from the brain than from other main metabolic organs. Collectively, our results provide a piece of evidence on the intrusion of exogeneous particles into the CNS and support the association between the inhalation of exogenous particles and their transport into the brain tissues. This work thus provides additional insights for the continued investigation of the adverse effects of air pollution on the brain.
关键词：enair pollutionparticulate mattersambient exposurebrain healthparticle retention