文章基本信息

标题：An overview on therapeutic efficacy and challenges of nanoparticles in blood cancer therapy
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作者：Jiaping Wang ; Lixia Sheng ; Yanli Lai 等
期刊名称：Journal of King Saud University - Science
印刷版ISSN：1018-3647
出版年度：2022
卷号：34
期号：6
页码：1-13
DOI：10.1016/j.jksus.2022.102182
语种：English
出版社：Elsevier
摘要：AbstractCancer is a disease with limited therapeutic options, despite tremendous improvements in medical research and technology. Cancer metastasis and recurrence are major causes of disability and death. Traditional cancer treatments have many limitations, prompting nanotechnology innovation for more precise and less harmful cancer treatment, also known as cancer nanomedicine. In recent years, novel biomolecule-stabilized nanomaterials have emerged as prominent next-generation materials. Nanoparticles, facilitated by advances in nanotechnology, provide possibilities for effective blood cancer therapy. Nanoparticles are amenable to modification. They can be designed to target and control the dose of drug that enter the target region. As a result, nanoparticles may enhance drug effectiveness while reducing negative effects. Several experimental difficulties must be overcome to get nanoparticle treatment to the bedside. Finally it is vital to develop effective formulations that can address the aforementioned concerns while also offering precision targeting of tumour areas without affecting healthy tissue survival. This review primarily focuses on thehighlights of current research progress using nanoparticles to deliver various blood cancer therapeutic medicines to illustrate nanoparticles' promise in leukemia, myeloma, and lymphoma therapy. Finally, we explore prospects and possible initiatives for potential therapeutic nanomedicine research.
关键词：KeywordsNanoparticleNanomaterialCancerLeukemiaMyelomaLymphomaTherapy