文章基本信息

标题：Synthesis and Configurational Stability of ( S )- and ( R )-Deuteriothalidomides
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作者：Takeshi Yamamoto ; Etsuko Tokunaga ; Shuichi Nakamura 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2010
卷号：58
期号：1
页码：110-112
DOI：10.1248/cpb.58.110
出版社：The Pharmaceutical Society of Japan
摘要：
3′-Deuteriothalidomide was synthesized and found to be configurationally five times more stable than thalidomide toward racemization at physiological pH.
关键词：thalidomide; isostere; deuterium