文章基本信息

标题：Regulation and Improvement of Cellulase Production: Recent Advances
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作者：Nasir Ali 1* , Muhammad Ammar Athar 1 , Yasir Hayat Khan 1 , Muhammad Idrees 2 , Dawood Ahmad
期刊名称：Natural Resources
印刷版ISSN：2158-706X
电子版ISSN：2158-7086
出版年度：2014
卷号：05
期号：14
页码：857-863
DOI：10.4236/nr.2014.514073
语种：English
出版社：Scientific Research Publishing
摘要：Cellulases and hemicellulases are the main industrial sources from different microorganisms used to depolymerise plant biomass to simple sugars that are converted to chemical intermediates and biofuels, such as ethanol. Cellulases are formed adaptively, and several positive (xyr1, Ace2, HAP2/3/5) and negative (Ace1, Cre1) components involved in this regulation are now known. In this review, we summarise current knowledge about how cellulase biosynthesis is regulated, and outline recent approaches and suitable strategies for facilitating the targeted improvement of cellulase production by genetic engineering. Trichoderma reesei is the preferred organism for producing industrial cellulases. However, a more efficient heterologous expression system for enzymes from different organism is needed to further improve its cellulase mixture. In addition those optimizations of the promoter and linker for hybrid genes can dramatically improve the efficiency of heterologous expression of cellulase genes.
关键词：Cellulase; Regulation; Transcription; Promoter; Review