文章基本信息

标题：Synthesis of New Dihydropyrazines with DNA Strand-Breakage Activity
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作者：Hiroshi Maruoka ; Nobuhiro Kashige ; Fumio Miake 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2005
卷号：53
期号：10
页码：1359-1361
DOI：10.1248/cpb.53.1359
出版社：The Pharmaceutical Society of Japan
摘要：
Treatment of 1,2-cyclohexanedione with 1,2-diamines, e.g. ethylenediamine and cis -(and trans -)1,2-diaminocyclohexane, caused [4+2] cyclocondensation to give the corresponding dihydropyrazine derivatives (compounds 1—6). They exhibited stronger DNA strand-breakage activity than that of dihydropyrazines, which has already been reported in previous papers.
关键词：dihydropyrazine; DNA strand-breakage; 1,2-diamine; α-diketone; cyclocondensation