文章基本信息

标题：Triterpenes and Lignans from Artemisia caruifolia and Their Cytotoxic Effects on Meth-A and LLC Tumor Cell Lines
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作者：Chao-mei MA ; Norio NAKAMURA ; Byung Sun MIN 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2001
卷号：49
期号：2
页码：183-187
DOI：10.1248/cpb.49.183
出版社：The Pharmaceutical Society of Japan
摘要：
One new triterpene, 3β-hydroxy-29-norcycloart-24-one (1), and four new lignans, caruilignans (2-5), together with six known compounds were isolated from the aerial part of Artemisia caruifolia BUCH.-HAM. ex TOXB. Their structures were determined by various spectroscopic means. Most of the isolated lignans were moderately cytotoxic to Meth-A cells with ED₅₀ values of 5-10 μg/ml, but not to Lowis lung carcinoma (LLC) cells. An oxime derivative of 1 showed more potent cytotoxic activity against Meth-A and LLC cells than the original triterpene 1.
关键词：Artemisia caruifolia; caruilignan; cytotoxicity; lignan; 3β-hydroxy-29-norcycloart-24-one