文章基本信息

标题：Immunomodulation and delivery of macrophages using nano-smooth drug-loaded magnetic microrobots for dual targeting cancer therapy
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作者：Xiaoxia Song ; Wei Fu ; U Kei Cheang 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：7
页码：1-16
DOI：10.1016/j.isci.2022.104507
语种：English
出版社：Elsevier
摘要：SummaryTo realize the potential to use micro/nanorobots for targeted cancer therapy, it is important to improve their biocompatibility and targeting ability. Here, we report on drug-loaded magnetic microrobots capable of polarizing macrophages into the antitumor phenotype to target and inhibit cancer cells.In vitrotests demonstrated that the microrobots have good biocompatibility with normal cells and immune cells. Positively charged DOX was loaded onto the surface of microrobots via electrostatic interactions and exhibited pH-responsive release behavior. The nano-smooth surfaces of the microrobots activated M1 polarization of macrophages, thus activating their intrinsic targeting and antitumor abilities toward cancer cells. Through dual targeting from magnetic guidance and M1 macrophages, the microrobots were able to target and kill cancer cells in a 3D tumor spheroid culture assay. These findings demonstrate a way to improve the tumor-targeting and antitumor abilities of microrobots through the combined use of magnetic control, macrophages, and pH-responsive drug release.Graphical abstractDisplay OmittedHighlights•Drug-loaded achiral magnetic microrobots developed with scalability and mass fabrication•Magnetic microrobot with nano-smooth surface can activate antitumor phenotype macrophage•The magnetic targeting and targeted therapy of polarized macrophages were combined•The magnetic microrobots exhibit enhanced tumor-targeting and antitumor capabilitiesDrug delivery system; Biological sciences; Immunology; Biotechnology; Cancer