文章基本信息

标题：A photo-triggering double cross-linked adhesive, antibacterial, and biocompatible hydrogel for wound healing
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作者：Honghua Hu ; Xinrang Zhai ; Wenyue Li 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：7
页码：1-17
DOI：10.1016/j.isci.2022.104619
语种：English
出版社：Elsevier
摘要：SummaryFull-thickness wounds, lacking the epidermis and entire dermis and extending into subcutaneous fat, represent a common treatment challenge. Due to the loss of adnexal structures as a source of keratinocytes, full-thickness wounds healing can only be achieved by re-epithelialization from the wound edge and contraction. Here, we developed a hydrogel composed of chitosan methacrylate (CSMA) ando-nitrosobenzaldehyde-modified gelatin (GelNB) for promoting full-thickness wound healing. The CSMA/GelNB (CM/GN) hydrogels exhibited superior mechanical and adhesive properties than that of pure CSMA hydrogel.In vivoexperiments confirmed that CM/GN could promote wound healing by generating more hair follicles and mutual blood vessels, high fibroblasts density, and thicker granulation tissue thickness. In addition, reduced secretions of tumor necrosis factor-α (TNF-α) and enhanced secretions of vascular endothelial growth factor (VEGF) could be observed in regenerated tissues after CM/GN treatment. These results suggested that CM/GN hydrogels could be promising candidates to promote wound healing.Graphical abstractDisplay OmittedHighlights•The CM/GN hydrogels exhibited tissue adhesive properties•CM/GN hydrogel facilitated the proliferation of bone marrow stem cells•CM/GN hydrogel efficiently promote full-thickness wound healing•More hair follicles and mutual blood vessels were generated during wound healingBiotechnology; Applied sciences; Bioengineering; Materials science; Biomaterials