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标题：Mesodiencephalic junction GABAergic inputs are processed separately from motor cortical inputs in the basilar pons
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作者：Ayoub J. Khalil ; Huibert D. Mansvelder ; Laurens Witter 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：7
页码：1-17
DOI：10.1016/j.isci.2022.104641
语种：English
出版社：Elsevier
摘要：SummaryThe basilar pontine nuclei (bPN) are known to receive excitatory input from the entire neocortex and constitute the main source of mossy fibers to the cerebellum. Various potential inhibitory afferents have been described, but their origin, synaptic plasticity, and network function have remained elusive. Here we identify the mesodiencephalic junction (MDJ) as a prominent source of monosynaptic GABAergic inputs to the bPN. We found no evidence that these inputs converge with motor cortex (M1) inputs at the single neuron or at the local network level. Tracing the inputs to GABAergic MDJ neurons revealed inputs to these neurons from neocortical areas. Additionally, we observed little short-term synaptic facilitation or depression in afferents from the MDJ, enabling MDJ inputs to carry sign-inversed neocortical inputs. Thus, our results show a prominent source of GABAergic inhibition to the bPN that could enrich input to the cerebellar granule cell layer.Graphical abstractDisplay OmittedHighlights•The basilar pontine nuclei (bPN) receive input from the mesodiencephalic junction (MDJ)•MDJ input to bPN is GABAergic and monosynaptic•Individual basilar bPN neurons do not integrate inputs from the motor cortex and MDJ•MDJ inputs to bPN most likely represent recoded cortical inputsPhysiology; Neuroscience; Cell biology