文章基本信息

标题：Genome-wide local ancestry and evidence for mitonuclear coadaptation in African hybrid cattle populations
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作者：James A. Ward ; Gillian P. McHugo ; Michael J. Dover 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：7
页码：1-18
DOI：10.1016/j.isci.2022.104672
语种：English
出版社：Elsevier
摘要：SummaryThe phenotypic diversity of African cattle reflects adaptation to a wide range of agroecological conditions, human-mediated selection preferences, and complex patterns of admixture between the humplessBos taurus(taurine) and humpedBos indicus(zebu) subspecies, which diverged 150–500 thousand years ago. Despite extensive admixture, all African cattle possess taurine mitochondrial haplotypes, even populations with significant zebu biparental and male uniparental nuclear ancestry. This has been interpreted as the result of human-mediated dispersal ultimately stemming from zebu bulls imported from South Asia during the last three millennia. Here, we assess whether ancestry at mitochondrially targeted nuclear genes in African admixed cattle is impacted by mitonuclear functional interactions. Using high-density SNP data, we find evidence for mitonuclear coevolution across hybrid African cattle populations with a significant increase of taurine ancestry at mitochondrially targeted nuclear genes. Our results, therefore, support the hypothesis of incompatibility between the taurine mitochondrial genome and the zebu nuclear genome.Graphical abstractDisplay OmittedHighlights•Using SNP data, we find evidence for mitonuclear coevolution in hybrid African cattle•Increased taurine ancestry at mitochondrially targeted nuclear genes in several breeds•Observed for genes encoding proteins that interact with mtDNA-encoded proteins•Our results support the hypothesis of mitonuclear incompatibility in African cattleEcology, Biological sciences, Genetics, Genomics, Evolutionary biology