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标题：Comparison of resting electroencephalogram coherence in patients with mild cognitive impairment and normal elderly subjects
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作者：Sugondo Hadiyoso ; Inung Wijayanto ; Suci Aulia 等
期刊名称：International Journal of Electrical and Computer Engineering
电子版ISSN：2088-8708
出版年度：2022
卷号：12
期号：2
页码：1558-1564
DOI：10.11591/ijece.v12i2.pp1558-1564
语种：English
出版社：Institute of Advanced Engineering and Science (IAES)
摘要：Mild cognitive impairment (MCI) was a condition beginning before more serious deterioration, leading to Alzheimer’s dementia (AD). MCI detection was needed to determine the patient's therapeutic management. Analysis of electroencephalogram (EEG) coherence is one of the modalities for MCI detection. Therefore, this study investigated the inter and intra-hemispheric coherence over 16 EEG channels in the frequency range of 1-30 Hz. The simulation results showed that most of the electrode pair coherence in MCI patients have decreased compared to normal elderly subjects. In inter hemisphere coherence, significant differences (p<0.05) were found in the FP1-FP2 electrode pairs. Meanwhile, significant differences (p<0.05) were found in almost all pre-frontal area connectivity of the intra-hemisphere coherence pairs. The electrode pairs were FP2-F4, FP2-T4, FP1-F3, FP1-F7, FP1-C3, FP1-T3, FP1-P3, FP1-T5, FP1-O1, F3-O1, and T3-T5. The decreased coherence in MCI patients showed the disconnection of cortical connections as a result of the death of the neurons. Furthermore, the coherence value can be used as a multimodal feature in normal elderly subjects and MCI. It is hoped that current studies may be considered for early detection of Alzheimer’s in a larger population.
关键词：alzheimer's dementia;coherence;electroencephalogram;mild cognitive impairment