文章基本信息

标题：Tissue plasminogen activator (tPA) treatment for COVID_19 associated acute respiratory distress syndrome (ARDS): A case report
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作者：Muhammad Mazharul Hoque ; Motiul Islam ; Tarikul Hamid 等
期刊名称：Bangladesh Critical Care Journal
印刷版ISSN：2307-7654
出版年度：2021
卷号：9
期号：1
页码：49-51
DOI：10.3329/bccj.v9i1.53059
语种：English
出版社：Bangladesh Society of Critical Care Medicine
摘要：Coagulopathy has proven to be a common complication of the novel coronavirus SARS-CoV-21. Some of the COVID-19 associated pneumonia patients exhibit relatively preserved lung compliance and high alveolar‐arterial oxygen gradient. Pathology reports consistently demonstrate diffuse pulmonary microthrombi on autopsy, consistent with a vascular occlusive etiology of respiratory failure rather than the more classic findings of ARDS2. Pulmonary microthrombi induced respiratory failure is very difficult to prove because the patients are so critically ill that transfer to CT suit to do CTPA often becomes unsafe for the patients. Moreover, performing V/Q scan is increasingly difficult in such settings. Here we report a case of severe COVID-19 associated respiratory failure who was treated with tissue plasminogen activator (tPA) on clinical ground.
关键词：Tissue plasminogen;tPA;ARDS;COVID‐19