文章基本信息

标题：Neuroprotective effects of Lepidium sativum L. on memory impairments in Wistar rat: Behavioral and neurochemical study
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作者：Soumia Ed-Day ; Samira Boulbaroud ; Latifa Didou 等
期刊名称：E3S Web of Conferences
印刷版ISSN：2267-1242
电子版ISSN：2267-1242
出版年度：2021
卷号：319
页码：1-4
DOI：10.1051/e3sconf/202131901015
语种：English
出版社：EDP Sciences
摘要：The present study investigated the effect of Lepidium sativum L. on Memory and on Acetylcholinesterase (AChE) activity in different brain structures among cadmium-exposed rats. Animals were divided into three groups: Control group (T): received a distilled water orally, Cadmium group (Cd): received oral administration dose of Cadmium Chloride (CdCl2) at 10 mg/kg, Protective group (Cd/LS): received CdCl2 (10mg/kg) and the aqueous extract of Lepidium sativum L. (20mg/kg) orally. The Novel Object Recognition Memory Test is used to evaluate the short and long term memory. The measure of AchE activity is realized by Ellman’s method. The results showed that subchronic Cadmium Chloride intoxication at a dose of 10 mg/kg caused a neurobehavioral impairments including: A significant decrease in the index of recognition of short-term (p2. A highly significant increase in the enzymatic activity of acetylcholinesterase in hippocampus, cerebellum, and cortex (pLepidium sativum L. may modulate the toxic effect induced by cadmium and consequently improve cognition.